![]() ![]() Therefore, tandem mass spectrometry methods might be considered as the goal standard for these analytes. ![]() Tandem mass spectrometric methods are accurate, selective, sensitive and rapid since analytes are separated depending on mz ratios rather than chromatographic separation. However, there have been problems with the stability of derivatives formed.Īnother important problem is that the separation of stereoisomer ADMA and SDMA can only be achieved chromatographically. In addition, as serum levels of these metabolites are low, sensitivity problems have been observed in HPLC methods. Since these metabolites are polar, they are difficult to retain in conventional reverse phase columns. In HPLC methods, solid phase extraction, derivatization and subsequent separation by reverse phase chromatography were performed. This review, HPLC and LC-MSMS methods developed for the measurement of methylarginine derivatives are discussed. ![]()
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